The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2013
Filed:
May. 04, 2010
John Powell, Cambridgeshire, GB;
Duncan Casson, Royston, GB;
Mark Maginn, Wilburton, GB;
Wei Liu, Mundelein, IL;
Sandeep Dutta, Gurnee, IL;
Andrea Best, Lake Forest, IL;
Jerry A. Hall, Gurnee, IL;
John Powell, Cambridgeshire, GB;
Duncan Casson, Royston, GB;
Mark Maginn, Wilburton, GB;
Wei Liu, Mundelein, IL;
Sandeep Dutta, Gurnee, IL;
Andrea Best, Lake Forest, IL;
Jerry A. Hall, Gurnee, IL;
Abbott Research B.V., Zwolle, NL;
Abstract
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.