The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2012
Filed:
Aug. 01, 2007
Marie-gabrielle Beuzelin-ollivier, Tolochenaz, CH;
Bastian Chevreux, Rheinfelden, DE;
Manuela Dalluege, Rheinfelden, DE;
Marina Van Gelder, TG Spijkenisse, NL;
Markus G. Goese, Basel, CH;
Corina Hauk, Weil am Rhein, DE;
Bertus P. Koekman, BG Schipluiden, NL;
Connie Lee, Reykjavik, IS;
Anne F. Mayer, Basel, CH;
Anja Meury, Basel, CH;
Nigel J. Mouncey, Binningen, CH;
Dick Schipper, HL Delft, NL;
Masako Shinjoh, Kanagawa, JP;
Christine Toepfer, Murg, DE;
Adrianus W. H. Vollebregt, BB Naaldwijk, NL;
Marie-Gabrielle Beuzelin-Ollivier, Tolochenaz, CH;
Bastian Chevreux, Rheinfelden, DE;
Manuela Dalluege, Rheinfelden, DE;
Marina Van Gelder, TG Spijkenisse, NL;
Markus G. Goese, Basel, CH;
Corina Hauk, Weil am Rhein, DE;
Bertus P. Koekman, BG Schipluiden, NL;
Connie Lee, Reykjavik, IS;
Anne F. Mayer, Basel, CH;
Anja Meury, Basel, CH;
Nigel J. Mouncey, Binningen, CH;
Dick Schipper, HL Delft, NL;
Masako Shinjoh, Kanagawa, JP;
Christine Toepfer, Murg, DE;
Adrianus W. H. Vollebregt, BB Naaldwijk, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.