The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2012
Filed:
Jun. 20, 2005
Arie Pieter Otte, Amersfoort, NL;
Theodorus Hendrikus Jacobus Kwaks, Amsterdam, NL;
Richard George Antonius Bernardus Sewalt, Arnhem, NL;
Arie Pieter Otte, Amersfoort, NL;
Theodorus Hendrikus Jacobus Kwaks, Amsterdam, NL;
Richard George Antonius Bernardus Sewalt, Arnhem, NL;
Chromagenics B.V., Leiden, NL;
Abstract
Described are means and methods for providing a cell with a protein expression unit, the method comprising providing a nucleic acid sequence comprising the unit with a nucleic acid sequence encoding a binding site for a member of a chromatin modification system for rendering chromatin more accessible for transcription (opener), wherein the opener is present in the cell. Preferred openers comprise histone modification proteins, chromatin remodeling proteins and trithorax group proteins or equivalents. The cells thus generated and nucleic acid sequences encoding such openers are provided. Openers are preferred in the context of STAR and TRAP sequences.