Company Filing History:
Years Active: 2008-2016
Title: Richard George Antonius Bernardus Sewalt: Innovator in Protein Expression Technologies
Introduction
Richard George Antonius Bernardus Sewalt is a notable inventor based in Arnhem, Netherlands. He has made significant contributions to the field of biotechnology, particularly in the area of protein expression. With a total of 7 patents, Sewalt's work has advanced the understanding and application of genetic engineering techniques.
Latest Patents
Sewalt's latest patents include innovative methods for selecting host cells that express proteins at high levels. One of his notable inventions describes a DNA molecule that comprises an open reading frame sequence encoding a selectable marker polypeptide. This DNA molecule features a translation start sequence with a GTG or TTG start codon. Additionally, the open reading frame sequence has been mutated to replace at least half of its CpG dinucleotides compared to the native sequence. His patents also cover methods for obtaining host cells that express a polypeptide of interest, which involves culturing these host cells with the described DNA molecules.
Another significant patent focuses on means and methods for producing proteins through chromatin openers. This invention provides a cell with a protein expression unit that includes a nucleic acid sequence encoding a binding site for a member of a chromatin modification system. The preferred openers in this context include histone modification proteins and chromatin remodeling proteins, which enhance the accessibility of chromatin for transcription factors.
Career Highlights
Sewalt is currently associated with Chromagenics B.V., where he continues to develop innovative solutions in biotechnology. His work has been instrumental in advancing techniques that improve protein expression, which is crucial for various applications in research and industry.
Collaborations
Throughout his career, Sewalt has collaborated with esteemed colleagues, including Arie Pieter Otte and Theodorus Hendrikus Jacobus Kwaks. These collaborations have further enriched his research and contributed to the success of his inventions.
Conclusion
Richard George Antonius Bernardus Sewalt is a prominent figure in the field of biotechnology, with a focus on protein expression technologies. His innovative patents and collaborations have significantly impacted the industry, paving the way for future advancements in genetic engineering.
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