The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2012
Filed:
Sep. 14, 2011
Masayuki Kai, Gunma, JP;
Kazuhiro Motoki, Gunma, JP;
Shiro Kataoka, Shibuya-ku, JP;
Hideaki Yoshida, Gunma, JP;
Tetsuya Hagiwara, Gunma, JP;
Masayuki Kai, Gunma, JP;
Kazuhiro Motoki, Gunma, JP;
Shiro Kataoka, Shibuya-ku, JP;
Hideaki Yoshida, Gunma, JP;
Tetsuya Hagiwara, Gunma, JP;
Kyowa Hakko Kirin Co., Ltd., Tokyo, JP;
Abstract
This invention provides an agonist antibody to a human thrombopoietin receptor (human c-Mpl), and pharmaceutical compositions comprising the same for use in treatment of thrombocytopenia. The disclosed agonist antibody comprises (1) antibody constant regions comprising heavy and light chain constant regions, each of which may optionally contain domain substitutions, or may contain deletions, substitutions, additions, or insertions of amino acid residues, and (2) antibody variable regions capable of binding to and activating a human thrombopoietin receptor. The-agonist antibody further induces colony formation at a concentration of 10,000 ng/ml or lower, and has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less.