The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2012
Filed:
Sep. 17, 2008
Chi-huey Wong, La Jolla, CA (US);
Yih-shyun E. Cheng, Taipei, TW;
Hui-ming Yu, Sijhih, TW;
Ting-jen R. Cheng, Taipei, TW;
Chung-yi Wu, Nankang, TW;
Jim-min Fang, Taipei, TW;
Chi-Huey Wong, La Jolla, CA (US);
Yih-Shyun E. Cheng, Taipei, TW;
Hui-Ming Yu, Sijhih, TW;
Ting-Jen R. Cheng, Taipei, TW;
Chung-Yi Wu, Nankang, TW;
Jim-Min Fang, Taipei, TW;
Academia Sinica, Nankang, TW;
Abstract
The crude extract of(PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation with PA crude extract resulted in significant inhibition of the LPS-induced expression of IL-6, IL-12, MCP-1, and RANTES in HUVEC cells. After the crude extract was further fractionated using preparative HPLC, fraction 8, 9, 10 and 11 were identified to inhibit the AP-1 binding activity. The active component of fraction 8 is Mena 987; fraction 9 is Mena 998; fraction 10 is Mena 9102; and fraction 11 is rosmarinic acid and the synthetic rosmarinic acid analogues. Other compounds showed inhibitory activities as well. These compounds have inhibitory effects on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression or activities of AP-1 are involved.