The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Apr. 02, 2004
Steven M. Friedman, West Chester, PA (US);
Peggy A. Scherle, Media, PA (US);
Xiangdong Liu, Metchuen, NJ (US);
Timothy C. Burn, Hockessin, DE (US);
Reid Huber, Wilmington, DE (US);
Phillip C. C. Liu, Wilmington, DE (US);
Gregory F. Hollis, Wilmington, DE (US);
Krishna Vaddi, Hockessin, DE (US);
Jordan S. Fridman, Newark, DE (US);
Steven M. Friedman, West Chester, PA (US);
Peggy A. Scherle, Media, PA (US);
Xiangdong Liu, Metchuen, NJ (US);
Timothy C. Burn, Hockessin, DE (US);
Reid Huber, Wilmington, DE (US);
Phillip C. C. Liu, Wilmington, DE (US);
Gregory F. Hollis, Wilmington, DE (US);
Krishna Vaddi, Hockessin, DE (US);
Jordan S. Fridman, Newark, DE (US);
Incyte Corporation, Wilmington, DE (US);
Abstract
The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.