The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Mar. 16, 2009
Eckard Wimmer, E. Setauket, NY (US);
Jeronimo Cello, Port Jefferson, NY (US);
Aniko Paul, Setauket, NY (US);
Hidemi Toyoda, E. Setauket, NY (US);
Jiang Yin, Port Jefferson, NY (US);
Eckard Wimmer, E. Setauket, NY (US);
Jeronimo Cello, Port Jefferson, NY (US);
Aniko Paul, Setauket, NY (US);
Hidemi Toyoda, E. Setauket, NY (US);
Jiang Yin, Port Jefferson, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
Abstract
A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5' non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2atumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.