The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Aug. 14, 2008
Vincent Dubois, Fleurus, BE;
Ann Marie Fernandez, Brussels, BE;
Sanjeev Gangwar, Foster City, CA (US);
Evan Lewis, Daly City, CA (US);
Thomas J. Lobl, Foster City, CA (US);
Matthew H. Nieder, Burlingame, CA (US);
Lesley B. Pickford, Menlo Park, CA (US);
Andre Trouet, Herentals, BE;
Geoffrey T. Yarranton, Burlingame, CA (US);
Vincent Dubois, Fleurus, BE;
Ann Marie Fernandez, Brussels, BE;
Sanjeev Gangwar, Foster City, CA (US);
Evan Lewis, Daly City, CA (US);
Thomas J. Lobl, Foster City, CA (US);
Matthew H. Nieder, Burlingame, CA (US);
Lesley B. Pickford, Menlo Park, CA (US);
Andre Trouet, Herentals, BE;
Geoffrey T. Yarranton, Burlingame, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.