The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Feb. 23, 2007
Zeling Cai, San Diego, CA (US);
Ann Moriarty, Poway, CA (US);
Per A. Peterson, Rancho Santa Fe, CA (US);
Jon M. Richards, Glenview, IL (US);
Zeling Cai, San Diego, CA (US);
Ann Moriarty, Poway, CA (US);
Per A. Peterson, Rancho Santa Fe, CA (US);
Jon M. Richards, Glenview, IL (US);
Janssen Pharmaceutica NV, , BE;
Abstract
In a cancer treatment combining cell therapy with chemotherapy, autologous CD8T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells loaded with selected peptide antigen, thereby generating antigen-specific activated cytotoxic T lymphocytes. Such activated CTLs are administered to the patient in conjunction with a lymphodepletion and CTL maintenance regimen comprising a non-myeloblative but lymphdepleting agent, such as cladribine or denileukin diftitox, and interleukin-2 and interferon-α-2b stimulatory cytokines.