The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Feb. 25, 2008
Robert F. Margolskee, Upper Montclair, NJ (US);
Liquan Huang, Havertown, PA (US);
Minqing Rong, Foster City, CA (US);
Marianna Max, Montclair, NJ (US);
Cristian A. Perez, New York, NY (US);
Robert F. Margolskee, Upper Montclair, NJ (US);
Liquan Huang, Havertown, PA (US);
Minqing Rong, Foster City, CA (US);
Marianna Max, Montclair, NJ (US);
Cristian A. Perez, New York, NY (US);
The Mount Sinai School of Medicine, New York, NY (US);
Abstract
The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant 'knock-out' animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.