The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2011
Filed:
Apr. 13, 2006
Jonas Korlach, Ithaca, NY (US);
Watt W. Webb, Ithaca, NY (US);
Michael Levene, Ithaca, NY (US);
Stephen Turner, Ithaca, NY (US);
Harold G. Craighead, Ithaca, NY (US);
Mathieu Foquet, Ithaca, NY (US);
Jonas Korlach, Ithaca, NY (US);
Watt W. Webb, Ithaca, NY (US);
Michael Levene, Ithaca, NY (US);
Stephen Turner, Ithaca, NY (US);
Harold G. Craighead, Ithaca, NY (US);
Mathieu Foquet, Ithaca, NY (US);
Cornell Research Foundation, Ithaca, NY (US);
Abstract
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid. Each type of labeled nucleotide comprises an acceptor fluorophore attached to a phosphate portion of the nucleotide such that the fluorophore is removed upon incorporation into a growing strand. Fluorescent signal is emitted via fluorescent resonance energy transfer between the donor fluorophore and the acceptor fluorophore as each nucleotide is incorporated into the growing strand. The sequence is deduced by identifying which base is being incorporated into the growing strand.