The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2011
Filed:
Apr. 25, 2006
John H. Adams, Granger, IN (US);
Malcolm J. Fraser, Granger, IN (US);
Bharath Balu, South Bend, IN (US);
Douglas A. Shoue, North Liberty, IN (US);
John H. Adams, Granger, IN (US);
Malcolm J. Fraser, Granger, IN (US);
Bharath Balu, South Bend, IN (US);
Douglas A. Shoue, North Liberty, IN (US);
University of Notre Dame du Lac, Notre Dame, IN (US);
Abstract
The present invention provides molecular methods for efficiently transforming the genome of common disease-transmitting parasites, such as. The transformation efficiencies are improved up to 100 times over those conventionally known. The methods provide high saturation of the target parasite genome, of 50% or greater, and target non-specifically TTAA-rich sites in the parasite genome. The invention also discloses a model that may be used to functionally annotate the genome of the, thus permitting the design and screening of compounds that may be useful in the control and inhibiting of diseases caused and transmitted by these parasites, including malaria. Highly efficient and multi-site integrating transposons, particularly piggyBac transposons, which provide for random and multi-site integration into parasite genomes in the presence of a helper plasmid, are also presented.