The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2011
Filed:
Jul. 24, 2009
Frank S. Walsh, Bryn Mawr, PA (US);
Margaret M. Zaleska, Narberth, PA (US);
David S. Howland, Yardley, PA (US);
Erika L. F. Holzbaur-howland, Yardley, PA (US);
Lioudmila Tchistiakova, Andover, MA (US);
Riyez Karim, North Andover, MA (US);
Pamela Kelley, Reading, MA (US);
William Kelley, Legal Representative, Reading, MA (US);
Xiang-yang Tan, Reading, MA (US);
Seung Poon Kwak, Ewing, NJ (US);
Karen Wallace, Newton Square, PA (US);
Nicholas Weber, Mountaintop, PA (US);
Menelas N. Pangalos, Pennington, NJ (US);
Frank S. Walsh, Bryn Mawr, PA (US);
Margaret M. Zaleska, Narberth, PA (US);
David S. Howland, Yardley, PA (US);
Erika L. F. Holzbaur-Howland, Yardley, PA (US);
Lioudmila Tchistiakova, Andover, MA (US);
Riyez Karim, North Andover, MA (US);
Pamela Kelley, Reading, MA (US);
William Kelley, legal representative, Reading, MA (US);
Xiang-Yang Tan, Reading, MA (US);
Seung Poon Kwak, Ewing, NJ (US);
Karen Wallace, Newton Square, PA (US);
Nicholas Weber, Mountaintop, PA (US);
Menelas N. Pangalos, Pennington, NJ (US);
WYETH LLC, Wilmington, DE (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.