The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2011
Filed:
Dec. 15, 2005
Dawn E. Bowles, Durham, NC (US);
Chengwen LI, Chapel Hill, NC (US);
Joseph E. Rabinowitz, Secane, PA (US);
Josh Grieger, Chapel Hill, NC (US);
Mavis Agbandje-mckenna, Gainesville, FL (US);
Richard Jude Samulski, Chapel Hill, NC (US);
Dawn E. Bowles, Durham, NC (US);
Chengwen Li, Chapel Hill, NC (US);
Joseph E. Rabinowitz, Secane, PA (US);
Josh Grieger, Chapel Hill, NC (US);
Mavis Agbandje-McKenna, Gainesville, FL (US);
Richard Jude Samulski, Chapel Hill, NC (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
The University of Florida Research Foundation, Gainesville, FL (US);
Abstract
The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.