The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2009
Filed:
May. 16, 2005
Grant A. Krafft, Glenview, IL (US);
William L. Klein, Winnetka, IL (US);
Brett A. Chromy, Evanston, IL (US);
Mary P. Lambert, Glenview, IL (US);
Caleb E. Finch, Altadena, CA (US);
Todd Morgan, Manhattan Beach, CA (US);
Pat Wals, Los Angeles, CA (US);
Irina Rozovsky, Pasadena, CA (US);
Ann Barlow, Evanston, IL (US);
Grant A. Krafft, Glenview, IL (US);
William L. Klein, Winnetka, IL (US);
Brett A. Chromy, Evanston, IL (US);
Mary P. Lambert, Glenview, IL (US);
Caleb E. Finch, Altadena, CA (US);
Todd Morgan, Manhattan Beach, CA (US);
Pat Wals, Los Angeles, CA (US);
Irina Rozovsky, Pasadena, CA (US);
Ann Barlow, Evanston, IL (US);
Northwestern University, Evanston, IL (US);
University of Southern California, Los Angeles, CA (US);
Abstract
The invention described in this disclosure involves a new composition of matter, amyloid beta-derived dementing ligands (ADDL's). ADDLs consist of amyloid β peptide assembled into soluble globular non-fibrillar oligomeric structures that are capable of activating specific cellular processes. The invention further encompasses methods for assaying the formation, presence, receptor protein binding and cellular activities of ADDLs. The invention further encompasses assay methods and inhibitor molecules for cellular signaling molecules activated by ADDLs. Also described are molecules that block proteins that promote the formation of ADDLs.