The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 23, 2008

Filed:

Dec. 15, 2003
Applicants:

Alastair Denholm, Horsham, GB;

Thomas Hugo Keller, Singapore, SG;

Clive Mccarthy, Basel, CH;

Neil John Press, Horsham, GB;

Roger John Taylor, Horsham, GB;

Inventors:

Alastair Denholm, Horsham, GB;

Thomas Hugo Keller, Singapore, SG;

Clive McCarthy, Basel, CH;

Neil John Press, Horsham, GB;

Roger John Taylor, Horsham, GB;

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/02 (2006.01); C07D 401/00 (2006.01); A61K 31/497 (2006.01); A61K 31/44 (2006.01); A01N 43/42 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of formula I in free or salt form, wherein R, Rand Rhave the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-α release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.


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