The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 09, 2007
Filed:
Jan. 22, 2002
Larry S. Barak, Durham, NC (US);
Robert H. Oakley, Durham, NC (US);
Marc G. Caron, Durham, NC (US);
Stephane A. Laporte, Outremont, CA;
Alyson Wilbanks, Chapel Hill, NC (US);
Larry S. Barak, Durham, NC (US);
Robert H. Oakley, Durham, NC (US);
Marc G. Caron, Durham, NC (US);
Stephane A. Laporte, Outremont, CA;
Alyson Wilbanks, Chapel Hill, NC (US);
Duke University, Durham, NC (US);
Abstract
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.