The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2007
Filed:
Mar. 15, 2001
Young Chul Sung, Kyungsangbuk-do, KR;
Sung Hee Lee, Seoul, KR;
Sang Jun Ha, Kyungsangbuk-do, KR;
Man Ki Song, Kyungsangbuk-do, KR;
Jun Chang, Kyungsangbuk-do, KR;
Young Chul Sung, Kyungsangbuk-do, KR;
Sung Hee Lee, Seoul, KR;
Sang Jun Ha, Kyungsangbuk-do, KR;
Man Ki Song, Kyungsangbuk-do, KR;
Jun Chang, Kyungsangbuk-do, KR;
Genexine Co., Ltd., Pohang, KR;
Abstract
The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant gene and the use of them to DNA vaccine adjuvant. Particularly, it relates to IL-12p40 mutant gene which inhibits the secretion of IL-12p40 but normally secretes active IL-12p70 by making mutation at Asn-222(human) or Asn-220(mouse) amino acid of IL-12p40, which acts as a competitive inhibitor of active form of IL-12, IL-12p70. Therefore, the IL-12p40 mutant gene of the present invention can be useful for DNA vaccination and gene therapy against various diseases, for example, AIDS, hepatitis C or hepatitis B, cancer, influenza, tuberculosis and malaria, which essentially require cellular immune responses for their therapy.