The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 2007
Filed:
Jun. 11, 2001
Christopher R. Bebbington, San Mateo, CA (US);
Vincent Dubois, Fleurus, BE;
Sanjeev Gangwar, Alameda, CA (US);
Thomas J. Lobl, Valencia, CA (US);
Matthew H. Nieder, Seattle, WA (US);
Lesley B. Pickford, Menlo Park, CA (US);
Andre Trouet, Herent, BE;
Geoffrey T. Yarranton, Burlingame, CA (US);
Christopher R. Bebbington, San Mateo, CA (US);
Vincent Dubois, Fleurus, BE;
Sanjeev Gangwar, Alameda, CA (US);
Thomas J. Lobl, Valencia, CA (US);
Matthew H. Nieder, Seattle, WA (US);
Lesley B. Pickford, Menlo Park, CA (US);
Andre Trouet, Herent, BE;
Geoffrey T. Yarranton, Burlingame, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.