The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 13, 2007

Filed:

May. 18, 2005
Applicants:

M. Robert Leanna, Grayslake, IL (US);

Michael Rasmussen, Kenosha, WI (US);

Steven M. Hannick, Highland Park, IL (US);

Jien-heh J. Tien, Vernon Hills, IL (US);

Kirill A. Lukin, Mundelein, IL (US);

Zhenping Tian, Grayslake, IL (US);

Sou-jen Chang, Prairie View, IL (US);

Cynthia B. Curty, Gurnee, IL (US);

Bikshandarkoil A. Narayanan, Mundelein, IL (US);

John Bellettini, Waukegan, IL (US);

Bhadra Shelat, Lake Forest, IL (US);

Tiffany Spitz, Highland Park, IL (US);

Inventors:

M. Robert Leanna, Grayslake, IL (US);

Michael Rasmussen, Kenosha, WI (US);

Steven M. Hannick, Highland Park, IL (US);

Jien-Heh J. Tien, Vernon Hills, IL (US);

Kirill A. Lukin, Mundelein, IL (US);

Zhenping Tian, Grayslake, IL (US);

Sou-Jen Chang, Prairie View, IL (US);

Cynthia B. Curty, Gurnee, IL (US);

Bikshandarkoil A. Narayanan, Mundelein, IL (US);

John Bellettini, Waukegan, IL (US);

Bhadra Shelat, Lake Forest, IL (US);

Tiffany Spitz, Highland Park, IL (US);

Assignee:

Medivir AB, Huddinge, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/18 (2006.01); C07D 473/40 (2006.01); C07F 7/18 (2006.01); C07C 69/66 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.


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