The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Dec. 10, 2001
Harry F. Noller, Santa Cruz, CA (US);
Jamie H. D. Cate, El Cerrito, CA (US);
Marat M. Yusupov, Strasbourg, FR;
Gulnara Zh. Yusupova, Strasbourg, FR;
Albion E. Baucom, Santa Cruz, CA (US);
Laura Lancaster, Santa Cruz, CA (US);
Anne Dallas, Santa Cruz, CA (US);
Kathy Lieberman, Santa Cruz, CA (US);
Harry F. Noller, Santa Cruz, CA (US);
Jamie H. D. Cate, El Cerrito, CA (US);
Marat M. Yusupov, Strasbourg, FR;
Gulnara Zh. Yusupova, Strasbourg, FR;
Albion E. Baucom, Santa Cruz, CA (US);
Laura Lancaster, Santa Cruz, CA (US);
Anne Dallas, Santa Cruz, CA (US);
Kathy Lieberman, Santa Cruz, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
5.5 Angstrom resolution x-ray crystallographic structures of 70S ribosome complexes containing messenger RNA and tranfer RNA (tRNA), or tRNA analogs, are provided. The resolution has been enhanced by fitting atomic resolution structures of 30S and 50S subunits onto the 5.5 anstrong electron density map. The enhanced structure reveals regions of structural differences between the 70S complex and the structures of the individual 30S and 50S components. Pharmacophore design to discover novel inhibitors or activators may be carried out using the enhanced 5.5 Angstrom 70S structure.