The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Apr. 12, 1994
Applicants:
Klaus Rajewsky, Cologne, DE;
Werner Mueller, Cologne, DE;
Juergen Roes, Cologne, DE;
Inventors:
Assignee:
Miltenyi Biotec GmbH, Bergisch Gladach, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01); A01K 67/027 (2006.01); A61K 39/00 (2006.01); C12N 5/06 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention provides novel methods of obtaining autologous monoclonal antibodies (AMABs) to self-antigens or homologs thereof. The method involves obtaining a genetically engineered host animal that does not biosynthesize at least one epitope of the antigen and utilizes the lack of self-tolerance of the host to the epitope to produce antibodies specific to the antigen. The invention also encompasses the AMABs produced by the methods. The invention further encompasses methods of isolating cells comprising the use of such AMABs that have specificity for a cell surface antigen.