The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2006
Filed:
Sep. 03, 2002
Dean J. Welsch, St. Peters, MO (US);
Kevin L. Duffin, Manchester, MO (US);
Olga V. Nemirovskiy, Wildwood, MO (US);
Dawn R. Dufield, O'Fallon, MO (US);
Teresa Sunyer, Wildwood, MO (US);
Carol Pearcy Howard, Fenton, MO (US);
Dean J. Welsch, St. Peters, MO (US);
Kevin L. Duffin, Manchester, MO (US);
Olga V. Nemirovskiy, Wildwood, MO (US);
Dawn R. Dufield, O'Fallon, MO (US);
Teresa Sunyer, Wildwood, MO (US);
Carol Pearcy Howard, Fenton, MO (US);
Pharmacia Corporation, St. Louis, MO (US);
Abstract
A method for identifying and quantifying peptides resulting from enzyme cleavage of collagen type II by mass spectrometric analysis to detect characteristic peptide fragments of a carboxy-terminus having known mass to charge ratios to identify the peptide having that carboxy-terminus. Identification and quantification of the peptides in a biological sample is used to assess activity of proteolytic enzymes in diseases or physiological conditions such as osteoarthritis and rheumatoid arthritis and to assess the efficacy of enzyme blocking agents.