The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 2006
Filed:
Jun. 21, 2000
Roberto Takashi Sudo, Rio de Janeiro, BR;
Edson X. Albuquerque, Baltimore, MD (US);
Eliezer J. DE Barreiro, Rio de Janeiro, BR;
Yasco Aracava, Rio de Janeiro, BR;
Wagner Monteiro Cintra, Rio de Janeiro, BR;
Paulo DE Assis Melo, Niteroi, BR;
Francois Germain Noel, Rio de Janeiro, BR;
Gisele Zapata Sudo, Rio de Janeiro, BR;
Claudia Lucia Martins Da Silva, Rio de Janeiro, BR;
Newton Goncalves DE Castro, Rio de Janeiro, BR;
Patricia Dias Fernandes, Rio de Janeiro, BR;
Carlos Alberto Manssour Fraga, Rio de Janeiro, BR;
Ana Luisa Palhares DE Miranda, Petropolis, BR;
Roberto Takashi Sudo, Rio de Janeiro, BR;
Edson X. Albuquerque, Baltimore, MD (US);
Eliezer J. De Barreiro, Rio de Janeiro, BR;
Yasco Aracava, Rio de Janeiro, BR;
Wagner Monteiro Cintra, Rio de Janeiro, BR;
Paulo De Assis Melo, Niteroi, BR;
Francois Germain Noel, Rio de Janeiro, BR;
Gisele Zapata Sudo, Rio de Janeiro, BR;
Claudia Lucia Martins Da Silva, Rio de Janeiro, BR;
Newton Goncalves de Castro, Rio de Janeiro, BR;
Patricia Dias Fernandes, Rio de Janeiro, BR;
Carlos Alberto Manssour Fraga, Rio de Janeiro, BR;
Ana Luisa Palhares De Miranda, Petropolis, BR;
University of Maryland, Baltimore, MD (US);
Abstract
The invention discloses a compound having the formula (I) wherein Ris selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; Ris selected from the group consisting of H, alkene, un-substituted phenol, and substituted phenyl; and pharmaceutically acceptable salts thereof, having digitalis-like properties. The invention further discloses a novel method to synthesize 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294). LASSBio-294 produces positive inotropic effect on cardiac and skeletal muscle. The invention is useful for the treatment of congestive heart failure and muscle fatigue. It lacks toxic effects seen in digitalis glycosides.