The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7065452 B1

Date of Patent:

Jun. 20, 2006

Filed:

Nov. 01, 1999

Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them

Applicants:

David M. Armistead, Maynard, MA (US);

Matthew James Fitzgibbon, Millis, MA (US);

Mark Andrew Fleming, Cambridge, MA (US);

James P. Griffith, Weston, MA (US);

Eunice E. Kim, Framingham, MA (US);

Joseph L. Kim, Natick, MA (US);

Michael D. Sintchak, Winchester, MA (US);

John Allan Thomson, Belmont, MA (US);

Keith P. Wilson, Hopkinton, MA (US);

Inventors:

David M. Armistead, Maynard, MA (US);

Matthew James Fitzgibbon, Millis, MA (US);

Mark Andrew Fleming, Cambridge, MA (US);

James P. Griffith, Weston, MA (US);

Eunice E. Kim, Framingham, MA (US);

Joseph L. Kim, Natick, MA (US);

Michael D. Sintchak, Winchester, MA (US);

John Allan Thomson, Belmont, MA (US);

Keith P. Wilson, Hopkinton, MA (US);

Assignee:

Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);

Attorneys:

James F. Haley, Jr.

Fish & Neave IP Group Ropes & Gray LLP

Primary Examiner:

Marjorie A Moran

Int. Cl.

CPC ...

G06G 7/48 (2006.01); G06N 7/06 (2006.01);

U.S. Cl.

CPC ...

Abstract

The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

Find Patent Forward Citations

Armistead, David. (2006). Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them (U.S. Patent No. 7065452). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7065452

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