The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Oct. 24, 2002
Renuka Pillutla, Bridgewater, NJ (US);
Renee Brissette, Clarksburg, NJ (US);
Michael Spruyt, Mahwah, NJ (US);
Olga Dedova, Highland Park, NJ (US);
Arthur Blume, Annandale, NJ (US);
John Prendergast, Lawrenceville, NJ (US);
Neil Goldstein, Maplewood, NJ (US);
Renuka Pillutla, Bridgewater, NJ (US);
Renee Brissette, Clarksburg, NJ (US);
Michael Spruyt, Mahwah, NJ (US);
Olga Dedova, Highland Park, NJ (US);
Arthur Blume, Annandale, NJ (US);
John Prendergast, Lawrenceville, NJ (US);
Neil Goldstein, Maplewood, NJ (US);
Antyra, Inc., Edison, NJ (US);
Abstract
The invention relates to a modified phage display method for detecting and identifying target and target binders. The modified methods involve transforming host cells with two separate phages of a target or target library and a target-binder library, and selecting to eliminate the non-paired targets and binders. The invention also relates to antibodies that bind to complexes of target and target binders; nucleic acids encoding target and target binders peptides; and the use of sequence information inherent in the targets and target binders for target validation using in silico approaches. The invention further relates to diagnostics and therapeutics employing the disclosed target and target binder peptides or polynucletides and their use in small molecule drug discovery; diagnostic and therapeutic applications directed to cancers and similar disorders; and site directed assays for high throughput drug screening.