The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2006
Filed:
Jun. 04, 2004
J. Albert Schultz, Houston, TX (US);
Michael V. Ugarov, Houston, TX (US);
Thomas F. Egan, Houston, TX (US);
Agnes Tempez, Houston, TX (US);
Yvon Le Beyec, Orsay, FR;
Serge Della-negra, Orsay, FR;
J. Albert Schultz, Houston, TX (US);
Michael V. Ugarov, Houston, TX (US);
Thomas F. Egan, Houston, TX (US);
Agnes Tempez, Houston, TX (US);
Yvon Le Beyec, Orsay, FR;
Serge Della-Negra, Orsay, FR;
Ionwerks, Inc., Houston, TX (US);
Abstract
The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.