The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2005
Filed:
Mar. 30, 1999
John D. Baxter, San Francisco, CA (US);
Beatrice Darimont, San Francisco, CA (US);
Weijun Feng, San Francisco, CA (US);
Robert J. Fletterick, San Francisco, CA (US);
Peter J. Kushner, San Francisco, CA (US);
Richard L. Wagner, San Francisco, CA (US);
Brian L. West, San Francisco, CA (US);
Keith R. Yamamoto, San Francisco, CA (US);
John D. Baxter, San Francisco, CA (US);
Beatrice Darimont, San Francisco, CA (US);
Weijun Feng, San Francisco, CA (US);
Robert J. Fletterick, San Francisco, CA (US);
Peter J. Kushner, San Francisco, CA (US);
Richard L. Wagner, San Francisco, CA (US);
Brian L. West, San Francisco, CA (US);
Keith R. Yamamoto, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention relates to methods and agonist/antagonist compounds for modulating nuclear receptor coactivator binding. The invention includes a method for identifying residues comprising a coactivator binding site for a nuclear receptor of interest. Also included is a method of identifying agonists and/or antagonists that bind to a coactivator binding site of a nuclear receptor of interest. Agonists and antagonists of coactivator binding to nuclear receptors also are provided. The invention is exemplified by identification and manipulation of the coactivator binding site of the thyroid receptor (TR), and compounds that bind to this sites. The methods can be applied to other nuclear receptors including RAR, RXR, PPAR, VDR, ER, GR, PR, MR, and AR.