The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2005
Filed:
Mar. 17, 2003
Thomas A. Steitz, Branford, CT (US);
Peter B. Moore, North Haven, CT (US);
Nenad Ban, Zürich, CH;
Poul Nissen, Aarhus, DK;
Jeffrey Hansen, New Haven, CT (US);
Thomas A. Steitz, Branford, CT (US);
Peter B. Moore, North Haven, CT (US);
Nenad Ban, Zürich, CH;
Poul Nissen, Aarhus, DK;
Jeffrey Hansen, New Haven, CT (US);
Yale University, New Haven, CT (US);
Abstract
The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of the crystals provided by the present invention are of sufficiently high resolution for determining the three-dimensional structure of ribosomes and ribosomal subunits, for identifying ligand binding sites on ribosomes and ribosomal subunits, and for molecular modeling of ligands which interact with ribosomes and ribosomal subunits. The present invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties. Thus, the methods of the present invention may be used to produce ligands which are designed to kill or inhibit any specific target organism(s).