The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2005
Filed:
Aug. 21, 2002
David A. Wink, Hagerstown, MD (US);
Martin Feelisch, Shreveport, LA (US);
David A. Kass, Columbia, MD (US);
Nazareno Paolocci, Baltimore, MD (US);
Katrina Miranda, Tucson, AZ (US);
Jon Fukuto, Agoura, CA (US);
Tatsuo Katori, Baltimore, MD (US);
David A. Wink, Hagerstown, MD (US);
Martin Feelisch, Shreveport, LA (US);
David A. Kass, Columbia, MD (US);
Nazareno Paolocci, Baltimore, MD (US);
Katrina Miranda, Tucson, AZ (US);
Jon Fukuto, Agoura, CA (US);
Tatsuo Katori, Baltimore, MD (US);
The United States of America as represented by the Secretary of the Department of Health and Human Services, Washington, DC (US);
The Regents of the University of California, Oakland, CA (US);
Johns Hopkins University, Baltimore, MD (US);
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Louisiana State University Health Sciences Center, Shreveport, LA (US);
Abstract
Administration of an HNO/NOdonating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure Moreover, administration of the HNO/NOdonating compound isopropylamine (IPA)/NO (Na(CH)CHNHN(O)NO) surprisingly exhibited positive inotropic effects in subjects experiencing heart failure that were superior to those caused by the HNO/NOdonating compound Angeli's salt. Additionally, in contrast to the effects observed with NOdonors, administration of an HNO/NOdonor in combination with a positive inotropic agent did not impair the positive inotropic effect of the positive inotropic agent Further, HNO/NOexerts its positive inotropic effect independent of the adrenergic system, increasing contractility even in subjects receiving beta-antagonist therapy