The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 23, 2005

Filed:

May. 16, 2003
Applicants:

Richard C. Egen, Cheyney, PA (US);

Lori Ann Fortin, Bethlehem, PA (US);

Willie Wei Qiang Sun, Easton, PA (US);

Inventors:

Richard C. Egen, Cheyney, PA (US);

Lori Ann Fortin, Bethlehem, PA (US);

Willie Wei Qiang Sun, Easton, PA (US);

Assignee:

Aventis Pasteur, Swiftwater, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N001/20 ; C12P021/00 ; C12P019/04 ; C12P019/26 ;
U.S. Cl.
CPC ...
Abstract

Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times the level observed with batch fermentation. This process is used successfully to produce polysaccharides ofserotypes, A, C, Y and W-135 and is run reproducibly at the 20 L scale and can be scaled to 400 L or more.


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