The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2005
Filed:
Jul. 18, 2001
Mario N. Lioubin, San Mateo, CA (US);
Lori Friedman, San Francisco, CA (US);
Marcia Belvin, Berkeley, CA (US);
Jeffery S. Larson, Burlingame, CA (US);
Changyou Chen, Castro Valley, CA (US);
Stephanie A. Robertson, San Francisco, CA (US);
Wen Shi, San Francisco, CA (US);
Jocelyn Chan, San Francisco, CA (US);
Danxi LI, San Francisco, CA (US);
Mario N. Lioubin, San Mateo, CA (US);
Lori Friedman, San Francisco, CA (US);
Marcia Belvin, Berkeley, CA (US);
Jeffery S. Larson, Burlingame, CA (US);
Changyou Chen, Castro Valley, CA (US);
Stephanie A. Robertson, San Francisco, CA (US);
Wen Shi, San Francisco, CA (US);
Jocelyn Chan, San Francisco, CA (US);
Danxi Li, San Francisco, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.