The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 14, 2004
Filed:
Nov. 08, 2000
Akihiro Kishishita, Kawasaki, JP;
Kazutaka Nagashima, Kawasaki, JP;
Hirotoshi Ishida, Kawasaki, JP;
Takeshi Nagai, Kawasaki, JP;
Ajinomoto Co., Inc., Tokyo, JP;
Abstract
For example, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester (A-type crystal) showing characteristic peaks in diffractive X-ray at diffraction angles (2&thgr;, CuK&agr; ray) of at least 6.0°, 24.8°, 8.2° and 16.5° is dried to its water content below 3% by weight. The crystal thus dried is a novel crystal (C-type crystal) of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester excellent in dissolution rate, and when measured by powder X-ray diffractometry, this crystal shows characteristic peaks in diffractive X-ray at diffraction angles (2&thgr;, CuK&agr; ray) of at least 7.1°, 19.8°, 17.3° and 17.7°. The dissolution rate (solubility) of the C-type crystals is further improved by converting the crystals into granules.