The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2002
Filed:
Oct. 06, 2000
Applicant:
Inventors:
Qinjian Zhao, Ambler, PA (US);
Shilu Wu, Collegeville, PA (US);
Walter Manger, Harleysville, PA (US);
Shishir Gadam, Harleysville, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/912 ; C12Q 1/70 ; C12Q 7/06 ; C12Q 7/02 ; C07K 1/14 ;
U.S. Cl.
CPC ...
A61K 3/912 ; C12Q 1/70 ; C12Q 7/06 ; C12Q 7/02 ; C07K 1/14 ;
Abstract
Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.