The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2001
Filed:
Jun. 11, 1999
Glenn J. Dorin, San Rafael, CA (US);
Bo H. Arve, Cary, NC (US);
Gregory L. Pattison, Oakland, CA (US);
Robert F Halenbeck, San Rafael, CA (US);
Kirk Johnson, Moraga, CA (US);
Bao-Lu Chen, San Ramon, CA (US);
Rajsharan K. Rana, Woodinville, WA (US);
Maninder S. Hoba, Danville, CA (US);
Hassan Madani, Seattle, WA (US);
Michael Tsang, San Francisco, CA (US);
Mark E. Gustafson, St. Charles, MO (US);
Gary S. Bild, Chesterfield, MO (US);
Gary V. Johnson, Charles, MO (US);
Other;
Abstract
A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.