The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 25, 2001
Filed:
Aug. 25, 1998
Timothy Mark Willson, Durham, NC (US);
Robert Anthony Mook, Chapel Hill, NC (US);
Istvan Kaldor, Durham, NC (US);
Brad Richard Henke, Cary, NC (US);
David Norman Deaton, Cary, NC (US);
Jon Loren Collins, Durham, NC (US);
Jeffrey Edmond Cobb, Chapel Hill, NC (US);
Marcus Brackeen, Durham, NC (US);
Matthew Jude Sharp, Apex, NC (US);
John Mark O'Callaghan, Kent, GB;
Greg Alan Erickson, Cary, NC (US);
Grady Evan Boswell, Cary, NC (US);
Glaxo Wellcome Inc., Research Triangle Park, NC (US);
Abstract
A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C,alkyl, C,alkoxy, C,fluoroalkoxy, nitrile, or —NR,R,where R,and R,are independently hydrogen or C,alkyl; (ii) a 5- or 6-membered hetrocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur; and (iii) a fused bicyclic ring (a), wherein ring C represents a heterocyclic group as defined in point (ii) above, which bicyclic ring is attached to group B via a ring atom of ring C; B is selected from the group consisting of: (iv) C,alkylene; (v) —MC,alkylene or C,alkyleneMC,alkylene, wherein M is O, S, or —NR,wherein R,represents hydrogen or C,alkyl; (vi) a 5- or 6-membered heterocyclic group containing at least one nitrogen heteroatom and optionally at least one further heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by C,alkyl; and (vii) Het-C,alkylene, wherein Het represents a heterocyclic group as defined in point (vi) above; Alk represents C,alkylene; R,represents hydrogen or C,alkyl; Z is selected from the group consisting of: (viii) —(C,alkylene) phenyl, which phenyl is optionally substituted by one or more halogen atoms; and (ix) —NR,R,, wherein R,represents hydrogen or C,alkyl, and R,represents —Y—(C═O)—T—R,, or —Y—(CH(OH))—T—R,.