The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2001
Filed:
Dec. 15, 1997
Changwon Kang, Taejon, KR;
Young-Soo Kwon, Kwangju, KR;
Young Tae Kim, Seoul, KR;
Hubert Köster, La Jolla, CA (US);
Daniel P. Little, Patton, PA (US);
Maryanne J. Little, Groton, MA (US);
Guobing Xiang, San Diego, CA (US);
David M. Lough, Eyemouth, GB;
Charles Cantor, Boston, MA (US);
Sequenom, Inc., San Diego, CA (US);
Abstract
A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.