The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2000
Filed:
Jul. 19, 1999
Applicant:
Inventors:
Ann Boriack-Sjodin, Waltham, MA (US);
S Mariana Margarit, Setauket, NY (US);
Dafna Bar-Sagi, Stony Brook, NY (US);
Philip Cole, Baltimore, MD (US);
John Kuriyan, Riverdale, NY (US);
Assignees:
The Rockefeller University, New York, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435195 ; 530350 ; 435 18 ;
Abstract
A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.