The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2000
Filed:
Jul. 23, 1998
Applicant:
Inventors:
Yuan-Peng Zhang, Mountain View, CA (US);
Peter Scherrer, Vancouver, CA;
Michael J Hope, Vancouver, CA;
Assignee:
Inex Pharmaceuticals Corp., Burnaby, CA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; A61K / ; A61K / ; B01J / ; B01J / ; C07H / ;
U.S. Cl.
CPC ...
435458 ; 435 911 ; 435 9131 ; 435325 ; 4353201 ; 424 932 ; 424450 ; 264-41 ; 935 52 ; 935 54 ; 536 231 ; 536 245 ; 514 44 ;
Abstract
This invention relates to a novel Solvent Extraction and Direct Hydration (SEDH) method for preparing lipid-nucleic acid particles which are useful for the introduction of nucleic acids (e.g., plasmid DNA, antisense molecules, ribozymes, etc.) into cells. The lipid-nucleic acid particles prepared using the methods of the present invention have enhanced circulation characteristics and serum stability and, thus, they are extremely effective as nucleic acid delivery vehicles.