The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2000
Filed:
Jul. 02, 1997
Paul M Simon, Wilmington, DE (US);
Edward J McGuire, Furlong, PA (US);
Neose Technologies, Inc., Horsham, PA (US);
Abstract
The invention relates to methods for attenuating xenograft rejection in humans and old world monkeys, using oligosaccharides containing a Gal.alpha.1-3Gal motif, to neutralize or remove anti-.alpha.Gal antibodies. The invention additionally relates to methods for site directed activation of the complement cascade or host leukocytes using oligosaccharides containing a Gal.alpha.1-3Gal motif to target anti-.alpha.Gal antibodies. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention. Such compositions contain, as the active ingredient, an oligosaccharide containing a Gal.alpha.1-3Gal motif effective in binding anti-.alpha.Gal antibodies in vivo or ex vivo.