The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2000
Filed:
Mar. 19, 1997
Carlo Brugnara, Newton Highlands, MA (US);
Jose Halperin, Brookline, MA (US);
Emile M Bellot, Jr, Beverly, MA (US);
Mark Froimowitz, Newton Centre, MA (US);
Richard John Lombardy, Waltham, MA (US);
John J Clifford, Bedford, MA (US);
Ying-Duo Gao, Neshanic Station, NJ (US);
Reem M Haidar, Malden, MA (US);
Eugene W Kelleher, Somerville, MA (US);
Falguni M Kher, Chelmsford, MA (US);
Adel M Moussa, Burlington, MA (US);
Yesh P Sachdeva, Concord, MA (US);
Minghua Sun, Cambridge, MA (US);
Heather N Taft, Littleton, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Ion Pharmaceuticals, Inc., New York, NY (US);
Abstract
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.