The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 1999
Filed:
Jun. 06, 1995
Douglas T Fearon, Baltimore, MD (US);
Lloyd B Klickstein, Brookline, MA (US);
Winnie W Wong, Newton, MA (US);
Gerald R Carson, Wellesley, MA (US);
Michael F Concino, Newton, MA (US);
Stephen H Ip, Sudbury, MA (US);
Savvas C Makrides, Bedford, MA (US);
Henry C Marsh, Jr, Reading, MA (US);
The Johns Hopkins University, Baltimore, MD (US);
The Brigham & Women's Hospital, Boston, MA (US);
Avant Immunotherapeutics, Inc., Needham, MA (US);
Abstract
The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention further provides for the expression of the CR1 protein and fragments thereof. The genes and proteins of the invention have uses in diagnosis and therapy of disorders involving complement activity, and various immune system or inflammatory disorders. In specific embodiments of the present invention detailed in the examples sections infra, the cloning, nucleotide sequence, and deduced amino acid sequence of a full-length CR1 cDNA and fragments thereof are described. The expression of the CR1 protein and fragments thereof is also described. Also described is the expression of a secreted CR1 molecule lacking a transmembrane region. The secreted CR1 molecule is shown to be useful in reducing damage caused by inflammation and in reducing myocardial infarct size and preventing reperfusion injury.