The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 1997
Filed:
Jul. 15, 1996
Paul M Lizardi, Colonia Rancho Cortez Cuernavaca, MX;
Sanjay Tyagi, New York, NY (US);
Ulf D Landegren, Uppsala, SE;
Fred R Kramer, Riverdale, NY (US);
Jack W Szostak, Boston, MA (US);
The Public Health Research Institute of the City of New York, Inc., New York, NY (US);
Abstract
There are provided nucleic acid hybridization assays for RNA targets using RNA binary probes and a ribozyme ligase that is a stringent RNA-directed RNA ligase. Preferred assays include exponential amplification for signal generation. Tetrahymena ribozyme ligase is a preferred ligase for use in this invention. It may be tethered to hold it close to the ligation junction. One assay according to this invention is a 'tethered ligase chain reaction.' Also provided are kits for performing assays according to the invention.