The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 1996
Filed:
Apr. 25, 1988
Philip E Auron, Middlesex County, MA (US);
Charles A Dinarello, Suffolk County, MA (US);
Andrew C Webb, Norfolk County, MA (US);
Alexander Rich, Middlesex County, MA (US);
Sheldon M Wolff, Norfolk County, MA (US);
New England Medical Centers Hospitals, Inc., Boston, MA (US);
Trustees of Tufts College, Boston, MA (US);
Wellesley College, Wellesley, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes-stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells.