The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 1994
Filed:
Aug. 27, 1992
Applicant:
Inventors:
Lee Josephson, Arlington, MA (US);
Ernest V Groman, Brookline, MA (US);
Chu Jung, Arlington, MA (US);
Jerome M Lewis, Newton, MA (US);
Assignee:
Advanced Magnetics Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K / ;
U.S. Cl.
CPC ...
424488 ; 424646 ; 435178 ; 514-2 ; 514 21 ; 514 54 ; 514169 ; 514179 ; 536 551 ;
Abstract
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.