The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 1994
Filed:
Aug. 25, 1989
Nadir Mrabet, Koekelberg, BE;
Ignace Lasters, Perk, BE;
Patrick Stanssens, St.-Denijs-Westrem, BE;
Gaston Matthyssens, St.-Genesius-Rhode, BE;
Shoshana Wodak, Brussels, BE;
Wilhelmus J Quax, Voorschoten, NL;
Plant Genetic Systems, Brussels, BE;
Gist-brocades, Delft, NL;
Abstract
The invention pertains to a method for the production of a biologically active modified protein derived from a starting protein having essentially the same kind of biological activity with an attendant modulation effect on, particularly increase of, the stability as compared with that of the starting protein. The method comprises substituting an arginine residue for a lysine residue of the starting protein at a site that can sterically accommodate the substitution, without substantially altering the biological activity of the starting protein, said site being preferably of low solvent accessibility, at interfaces between domains or sub-units of the starting protein.