The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 1993
Filed:
Apr. 01, 1993
Peter M Clarke, Radcliffe on Trent, GB;
David J Mead, Radcliffe on Trent, GB;
Stephen H Collins, Radcliffe on Trent, GB;
Delta Biotechnology Limited, Nottingham, GB;
Abstract
The recoverable yield of recombinant human albumin in the fermentation of genetically engineered yeast that expresses the albumin and secretes it into the culture medium is increased by the addition of a stabilizing agent comprising a polyoxyalkylene compound, for example, polypropylene glycol or a polyoxypropylene/polyoxyethylene copolymer. The presence of these compounds in concentrations of from about 0.5 to 10 g per liter, preferably 1 to 5 g per liter, of fermentation broth prevents the degradation of the rHA produced under intensive fermentation conditions thereby raising the effective yield.