The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 1987
Filed:
Sep. 21, 1984
Applicant:
Inventors:
Jan Verweij, Leiden, NL;
Herman H Grootveld, Benthuizen, NL;
Henri G Hirs, Zoetermeer, NL;
Gerardus J Van Veen, Zoetermeer, NL;
Jan Kalter, Hazerswoude-Dorp, NL;
Peter W Henniger, Leiden, NL;
Assignee:
Gist-Brocades N.V., Delft, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ;
U.S. Cl.
CPC ...
540224 ; 540215 ; 540222 ; 540225 ; 540226 ; 540227 ; 540228 ; 540229 ; 540230 ; 2041577 ;
Abstract
A process for the preparation of 7.beta.-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70.degree. C. to 0.degree. C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.