The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2026

Filed:

Nov. 12, 2020
Applicant:

Wuhan Ll Science and Technology Development Co., Ltd., Wuhan, CN;

Inventors:

Jinping Li, Wuhan, CN;

Jun Lou, WUhan, CN;

Xiaodan Guo, Wuhan, CN;

Xian Zeng, Wuhan, CN;

Yongkai Chen, Wuhan, CN;

Yihan Zhang, Wuhan, CN;

Wei Peng, Wuhan, CN;

Chaodong Wang, Wuhan, CN;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 413/04 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 487/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The compound represented by formula (I), and racemates, stereoisomers, tautomers, isotopic markers, nitrogen oxides, solvates, polymorphs, metabolites, esters, pharmaceutically acceptable salts, or prodrugs thereof have ROCK inhibitory activity. The compound represented by formula (1) has good safety, good metabolic stability, and a low risk of potential hepatotoxicity. Further, the compound represented by formula (I) has a simple preparation method and is easy to purify, and therefore has good application prospects.


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